San Diego Padres probable pitchers and starting lineup vs. Chicago Cubs, June 3

San Diego Padres starting pitcher Yu Darvish
San Diego Padres starting pitcher Yu Darvish / Geoff Burke-USA TODAY Sports

After a frustrating 2-1 loss to the Chicago Cubs on Friday night, the San Diego Padres will look to earn a win and even up the four-game series on Saturday night at Petco Park.

So far this season, the Cubs have won three of their four meetings against the Padres, including Friday night's low-scoring encounter when the teams combined for eight total hits. San Diego has scored just eight runs in the four meetings with the Cubs this season (Chicago, meanwhile, has scored 16).

Saturday night's matchup is set for 7:10 p.m. (San Diego time)/9:10 p.m. (Chicago time) and can be seen for free on or as well as through Chicago's broadcast on the Marquee Sports Network. Additionally, the game will be available nationally on FS1 (blackout rules may exist).

San Diego Padres vs. Chicago Cubs starting lineups for June 3

Here is the Chicago lineup for Saturday...

Here is the San Diego lineup for Saturday...

San Diego Padres vs. Chicago Cubs starting pitchers for June 3

For the Cubs, Drew Smyly (5-2, 3.45 ERA) is expected to take the mound. The 33-year-old southpaw is 3-1 with a 3.65 ERA over his last 37.0 innings pitched and has already faced the Padres once this season, scattering two runs and four hits over 5.0 innings on April 26 at Wrigley Field.

San Diego will counter with 36-year-old right-hander Yu Darvish, who is 3-4 with a 4.61 ERA in 10 starts so far this season. Darvish did not pitch against the Cubs in the earlier meetings this season.

San Diego Padres vs. Chicago Cubs numbers to know

Juan Soto has struggled against Smyly in his career, batting just .083 in 12 at-bats. However, the Padres slugger does have a home run against him.

On the opposite side, Cubs catcher Yan Gomes has feasted on Darvish in previous meetings, posting a .455 average in 11 at-bats, including a home run.

Also, as our friends at BetSided mentioned in this article, there is a glimmer of hope for the Padres offense tonight. As a team this season, San Diego's OPS increases from .672 against right-handed pitchers to .740 against lefties (such as Smyly).